Fujisawa Misa experiences premenstrual syndrome once a month. During those times, she tries to deal with her uncontrolled irritation at understanding her colleagues at work. Yamazoe Takatoshi suffers from panic disorder. Due to that, he gives up on many things in his life and carries a lethargic attitude to his life. Becoming aware of each other’s situation, Yamazoe and Fujisawa begin to share a bond and try to help each other.